Rociletinib in EGFR-mutated non-small-cell lung cancer.
Identifieur interne : 002862 ( Main/Exploration ); précédent : 002861; suivant : 002863Rociletinib in EGFR-mutated non-small-cell lung cancer.
Auteurs : Lecia V. Sequist [France] ; Jean-Charles Soria ; Jonathan W. Goldman ; Heather A. Wakelee ; Shirish M. Gadgeel ; Andrea Varga ; Vassiliki Papadimitrakopoulou ; Benjamin J. Solomon ; Geoffrey R. Oxnard ; Rafal Dziadziuszko ; Dara L. Aisner ; Robert C. Doebele ; Cathy Galasso ; Edward B. Garon ; Rebecca S. Heist ; Jennifer Logan ; Joel W. Neal ; Melody A. Mendenhall ; Suzanne Nichols ; Zofia Piotrowska ; Antoinette J. Wozniak ; Mitch Raponi ; Chris A. Karlovich ; Sarah Jaw-Tsai ; Jeffrey Isaacson ; Darrin Despain ; Shannon L. Matheny ; Lindsey Rolfe ; Andrew R. Allen ; D Ross CamidgeSource :
- The New England journal of medicine [ 1533-4406 ] ; 2015.
Descripteurs français
- KwdFr :
- Acrylamides (administration et posologie), Acrylamides (effets indésirables), Acrylamides (pharmacocinétique), Adulte d'âge moyen, Antinéoplasiques (administration et posologie), Antinéoplasiques (effets indésirables), Carcinome pulmonaire non à petites cellules (anatomopathologie), Carcinome pulmonaire non à petites cellules (génétique), Carcinome pulmonaire non à petites cellules (traitement médicamenteux), Femelle, Humains, Hyperglycémie (), Inhibiteurs de protéines kinases (administration et posologie), Inhibiteurs de protéines kinases (effets indésirables), Inhibiteurs de protéines kinases (pharmacocinétique), Mutation, Mâle, Pyrimidines (administration et posologie), Pyrimidines (effets indésirables), Pyrimidines (pharmacocinétique), Relation dose-effet des médicaments, Récepteur du facteur de croissance épidermique (antagonistes et inhibiteurs), Récepteur du facteur de croissance épidermique (génétique), Résistance aux médicaments antinéoplasiques (génétique), Sujet âgé, Tumeurs du poumon (anatomopathologie), Tumeurs du poumon (génétique), Tumeurs du poumon (traitement médicamenteux).
- MESH :
- administration et posologie : Acrylamides, Antinéoplasiques, Inhibiteurs de protéines kinases, Pyrimidines.
- anatomopathologie : Carcinome pulmonaire non à petites cellules, Tumeurs du poumon.
- antagonistes et inhibiteurs : Récepteur du facteur de croissance épidermique.
- effets indésirables : Acrylamides, Antinéoplasiques, Inhibiteurs de protéines kinases, Pyrimidines.
- génétique : Carcinome pulmonaire non à petites cellules, Récepteur du facteur de croissance épidermique, Résistance aux médicaments antinéoplasiques, Tumeurs du poumon.
- pharmacocinétique : Acrylamides, Inhibiteurs de protéines kinases, Pyrimidines.
- traitement médicamenteux : Carcinome pulmonaire non à petites cellules, Tumeurs du poumon.
- Adulte d'âge moyen, Femelle, Humains, Hyperglycémie, Mutation, Mâle, Relation dose-effet des médicaments, Sujet âgé.
English descriptors
- KwdEn :
- Acrylamides (administration & dosage), Acrylamides (adverse effects), Acrylamides (pharmacokinetics), Aged, Antineoplastic Agents (administration & dosage), Antineoplastic Agents (adverse effects), Carcinoma, Non-Small-Cell Lung (drug therapy), Carcinoma, Non-Small-Cell Lung (genetics), Carcinoma, Non-Small-Cell Lung (pathology), Dose-Response Relationship, Drug, Drug Resistance, Neoplasm (genetics), Female, Humans, Hyperglycemia (chemically induced), Lung Neoplasms (drug therapy), Lung Neoplasms (genetics), Lung Neoplasms (pathology), Male, Middle Aged, Mutation, Protein Kinase Inhibitors (administration & dosage), Protein Kinase Inhibitors (adverse effects), Protein Kinase Inhibitors (pharmacokinetics), Pyrimidines (administration & dosage), Pyrimidines (adverse effects), Pyrimidines (pharmacokinetics), Receptor, Epidermal Growth Factor (antagonists & inhibitors), Receptor, Epidermal Growth Factor (genetics).
- MESH :
- chemical , administration & dosage : Acrylamides, Antineoplastic Agents, Protein Kinase Inhibitors, Pyrimidines.
- chemical , adverse effects : Acrylamides, Antineoplastic Agents, Protein Kinase Inhibitors, Pyrimidines.
- chemical , antagonists & inhibitors : Receptor, Epidermal Growth Factor.
- chemical , genetics : Receptor, Epidermal Growth Factor.
- chemical , pharmacokinetics : Acrylamides, Protein Kinase Inhibitors, Pyrimidines.
- chemically induced : Hyperglycemia.
- drug therapy : Carcinoma, Non-Small-Cell Lung, Lung Neoplasms.
- genetics : Carcinoma, Non-Small-Cell Lung, Drug Resistance, Neoplasm, Lung Neoplasms.
- pathology : Carcinoma, Non-Small-Cell Lung, Lung Neoplasms.
- Aged, Dose-Response Relationship, Drug, Female, Humans, Male, Middle Aged, Mutation.
Abstract
Non-small-cell lung cancer (NSCLC) with a mutation in the gene encoding epidermal growth factor receptor (EGFR) is sensitive to approved EGFR inhibitors, but resistance develops, mediated by the T790M EGFR mutation in most cases. Rociletinib (CO-1686) is an EGFR inhibitor active in preclinical models of EGFR-mutated NSCLC with or without T790M.
DOI: 10.1056/NEJMoa1413654
PubMed: 25923550
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002E24
- to stream PubMed, to step Curation: 002D48
- to stream PubMed, to step Checkpoint: 002D48
- to stream Ncbi, to step Merge: 002513
- to stream Ncbi, to step Curation: 002513
- to stream Ncbi, to step Checkpoint: 002513
- to stream Main, to step Merge: 002862
- to stream Main, to step Curation: 002862
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Rociletinib in EGFR-mutated non-small-cell lung cancer.</title><author><name sortKey="Sequist, Lecia V" sort="Sequist, Lecia V" uniqKey="Sequist L" first="Lecia V" last="Sequist">Lecia V. Sequist</name><affiliation wicri:level="4"><nlm:affiliation>From Massachusetts General Hospital (L.V.S., R.S.H., J.L., Z.P.), Harvard Medical School (L.V.S., G.R.O., R.S.H., Z.P.), and Dana-Farber Cancer Institute (G.R.O.) - all in Boston; the Drug Development Department, Université Paris-Sud, Gustave Roussy Cancer Campus (J.-C.S.), and Institut Gustave Roussy (A.V.), Villejuif - both in France; the David Geffen School of Medicine, University of California, Los Angeles, Los Angeles (J.W.G., E.B.G., M.A.M., S.N.), and Stanford Cancer Institute, Stanford University, Stanford (H.A.W., J.W.N.) - both in California; the Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit (S.M.G., C.G., A.J.W.); University of Texas M.D. Anderson Cancer Center, Houston (V.P.); the Peter MacCallum Cancer Centre, Melbourne, VIC, Australia (B.J.S.); the Medical University of Gdansk, Gdansk, Poland (R.D.); the University of Colorado (D.L.A., D.R.C.) and University of Colorado Cancer Center (R.C.D.) - both in Aurora; and Clovis Oncology, San Francisco (M.R., C.A.K., S.J.-T., S.L.M., A.R.A.), Boulder, CO (J.I., D.D.), and Cambridge, United Kingdom (L.R.).</nlm:affiliation><orgName type="university">Université Paris-Sud</orgName><country>France</country><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Soria, Jean Charles" sort="Soria, Jean Charles" uniqKey="Soria J" first="Jean-Charles" last="Soria">Jean-Charles Soria</name></author><author><name sortKey="Goldman, Jonathan W" sort="Goldman, Jonathan W" uniqKey="Goldman J" first="Jonathan W" last="Goldman">Jonathan W. Goldman</name></author><author><name sortKey="Wakelee, Heather A" sort="Wakelee, Heather A" uniqKey="Wakelee H" first="Heather A" last="Wakelee">Heather A. Wakelee</name></author><author><name sortKey="Gadgeel, Shirish M" sort="Gadgeel, Shirish M" uniqKey="Gadgeel S" first="Shirish M" last="Gadgeel">Shirish M. Gadgeel</name></author><author><name sortKey="Varga, Andrea" sort="Varga, Andrea" uniqKey="Varga A" first="Andrea" last="Varga">Andrea Varga</name></author><author><name sortKey="Papadimitrakopoulou, Vassiliki" sort="Papadimitrakopoulou, Vassiliki" uniqKey="Papadimitrakopoulou V" first="Vassiliki" last="Papadimitrakopoulou">Vassiliki Papadimitrakopoulou</name></author><author><name sortKey="Solomon, Benjamin J" sort="Solomon, Benjamin J" uniqKey="Solomon B" first="Benjamin J" last="Solomon">Benjamin J. Solomon</name></author><author><name sortKey="Oxnard, Geoffrey R" sort="Oxnard, Geoffrey R" uniqKey="Oxnard G" first="Geoffrey R" last="Oxnard">Geoffrey R. Oxnard</name></author><author><name sortKey="Dziadziuszko, Rafal" sort="Dziadziuszko, Rafal" uniqKey="Dziadziuszko R" first="Rafal" last="Dziadziuszko">Rafal Dziadziuszko</name></author><author><name sortKey="Aisner, Dara L" sort="Aisner, Dara L" uniqKey="Aisner D" first="Dara L" last="Aisner">Dara L. Aisner</name></author><author><name sortKey="Doebele, Robert C" sort="Doebele, Robert C" uniqKey="Doebele R" first="Robert C" last="Doebele">Robert C. Doebele</name></author><author><name sortKey="Galasso, Cathy" sort="Galasso, Cathy" uniqKey="Galasso C" first="Cathy" last="Galasso">Cathy Galasso</name></author><author><name sortKey="Garon, Edward B" sort="Garon, Edward B" uniqKey="Garon E" first="Edward B" last="Garon">Edward B. Garon</name></author><author><name sortKey="Heist, Rebecca S" sort="Heist, Rebecca S" uniqKey="Heist R" first="Rebecca S" last="Heist">Rebecca S. Heist</name></author><author><name sortKey="Logan, Jennifer" sort="Logan, Jennifer" uniqKey="Logan J" first="Jennifer" last="Logan">Jennifer Logan</name></author><author><name sortKey="Neal, Joel W" sort="Neal, Joel W" uniqKey="Neal J" first="Joel W" last="Neal">Joel W. Neal</name></author><author><name sortKey="Mendenhall, Melody A" sort="Mendenhall, Melody A" uniqKey="Mendenhall M" first="Melody A" last="Mendenhall">Melody A. Mendenhall</name></author><author><name sortKey="Nichols, Suzanne" sort="Nichols, Suzanne" uniqKey="Nichols S" first="Suzanne" last="Nichols">Suzanne Nichols</name></author><author><name sortKey="Piotrowska, Zofia" sort="Piotrowska, Zofia" uniqKey="Piotrowska Z" first="Zofia" last="Piotrowska">Zofia Piotrowska</name></author><author><name sortKey="Wozniak, Antoinette J" sort="Wozniak, Antoinette J" uniqKey="Wozniak A" first="Antoinette J" last="Wozniak">Antoinette J. Wozniak</name></author><author><name sortKey="Raponi, Mitch" sort="Raponi, Mitch" uniqKey="Raponi M" first="Mitch" last="Raponi">Mitch Raponi</name></author><author><name sortKey="Karlovich, Chris A" sort="Karlovich, Chris A" uniqKey="Karlovich C" first="Chris A" last="Karlovich">Chris A. Karlovich</name></author><author><name sortKey="Jaw Tsai, Sarah" sort="Jaw Tsai, Sarah" uniqKey="Jaw Tsai S" first="Sarah" last="Jaw-Tsai">Sarah Jaw-Tsai</name></author><author><name sortKey="Isaacson, Jeffrey" sort="Isaacson, Jeffrey" uniqKey="Isaacson J" first="Jeffrey" last="Isaacson">Jeffrey Isaacson</name></author><author><name sortKey="Despain, Darrin" sort="Despain, Darrin" uniqKey="Despain D" first="Darrin" last="Despain">Darrin Despain</name></author><author><name sortKey="Matheny, Shannon L" sort="Matheny, Shannon L" uniqKey="Matheny S" first="Shannon L" last="Matheny">Shannon L. Matheny</name></author><author><name sortKey="Rolfe, Lindsey" sort="Rolfe, Lindsey" uniqKey="Rolfe L" first="Lindsey" last="Rolfe">Lindsey Rolfe</name></author><author><name sortKey="Allen, Andrew R" sort="Allen, Andrew R" uniqKey="Allen A" first="Andrew R" last="Allen">Andrew R. Allen</name></author><author><name sortKey="Camidge, D Ross" sort="Camidge, D Ross" uniqKey="Camidge D" first="D Ross" last="Camidge">D Ross Camidge</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25923550</idno><idno type="pmid">25923550</idno><idno type="doi">10.1056/NEJMoa1413654</idno><idno type="wicri:Area/PubMed/Corpus">002E24</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002E24</idno><idno type="wicri:Area/PubMed/Curation">002D48</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002D48</idno><idno type="wicri:Area/PubMed/Checkpoint">002D48</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002D48</idno><idno type="wicri:Area/Ncbi/Merge">002513</idno><idno type="wicri:Area/Ncbi/Curation">002513</idno><idno type="wicri:Area/Ncbi/Checkpoint">002513</idno><idno type="wicri:Area/Main/Merge">002862</idno><idno type="wicri:Area/Main/Curation">002862</idno><idno type="wicri:Area/Main/Exploration">002862</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Rociletinib in EGFR-mutated non-small-cell lung cancer.</title><author><name sortKey="Sequist, Lecia V" sort="Sequist, Lecia V" uniqKey="Sequist L" first="Lecia V" last="Sequist">Lecia V. Sequist</name><affiliation wicri:level="4"><nlm:affiliation>From Massachusetts General Hospital (L.V.S., R.S.H., J.L., Z.P.), Harvard Medical School (L.V.S., G.R.O., R.S.H., Z.P.), and Dana-Farber Cancer Institute (G.R.O.) - all in Boston; the Drug Development Department, Université Paris-Sud, Gustave Roussy Cancer Campus (J.-C.S.), and Institut Gustave Roussy (A.V.), Villejuif - both in France; the David Geffen School of Medicine, University of California, Los Angeles, Los Angeles (J.W.G., E.B.G., M.A.M., S.N.), and Stanford Cancer Institute, Stanford University, Stanford (H.A.W., J.W.N.) - both in California; the Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit (S.M.G., C.G., A.J.W.); University of Texas M.D. Anderson Cancer Center, Houston (V.P.); the Peter MacCallum Cancer Centre, Melbourne, VIC, Australia (B.J.S.); the Medical University of Gdansk, Gdansk, Poland (R.D.); the University of Colorado (D.L.A., D.R.C.) and University of Colorado Cancer Center (R.C.D.) - both in Aurora; and Clovis Oncology, San Francisco (M.R., C.A.K., S.J.-T., S.L.M., A.R.A.), Boulder, CO (J.I., D.D.), and Cambridge, United Kingdom (L.R.).</nlm:affiliation><orgName type="university">Université Paris-Sud</orgName><country>France</country><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Soria, Jean Charles" sort="Soria, Jean Charles" uniqKey="Soria J" first="Jean-Charles" last="Soria">Jean-Charles Soria</name></author><author><name sortKey="Goldman, Jonathan W" sort="Goldman, Jonathan W" uniqKey="Goldman J" first="Jonathan W" last="Goldman">Jonathan W. Goldman</name></author><author><name sortKey="Wakelee, Heather A" sort="Wakelee, Heather A" uniqKey="Wakelee H" first="Heather A" last="Wakelee">Heather A. Wakelee</name></author><author><name sortKey="Gadgeel, Shirish M" sort="Gadgeel, Shirish M" uniqKey="Gadgeel S" first="Shirish M" last="Gadgeel">Shirish M. Gadgeel</name></author><author><name sortKey="Varga, Andrea" sort="Varga, Andrea" uniqKey="Varga A" first="Andrea" last="Varga">Andrea Varga</name></author><author><name sortKey="Papadimitrakopoulou, Vassiliki" sort="Papadimitrakopoulou, Vassiliki" uniqKey="Papadimitrakopoulou V" first="Vassiliki" last="Papadimitrakopoulou">Vassiliki Papadimitrakopoulou</name></author><author><name sortKey="Solomon, Benjamin J" sort="Solomon, Benjamin J" uniqKey="Solomon B" first="Benjamin J" last="Solomon">Benjamin J. Solomon</name></author><author><name sortKey="Oxnard, Geoffrey R" sort="Oxnard, Geoffrey R" uniqKey="Oxnard G" first="Geoffrey R" last="Oxnard">Geoffrey R. Oxnard</name></author><author><name sortKey="Dziadziuszko, Rafal" sort="Dziadziuszko, Rafal" uniqKey="Dziadziuszko R" first="Rafal" last="Dziadziuszko">Rafal Dziadziuszko</name></author><author><name sortKey="Aisner, Dara L" sort="Aisner, Dara L" uniqKey="Aisner D" first="Dara L" last="Aisner">Dara L. Aisner</name></author><author><name sortKey="Doebele, Robert C" sort="Doebele, Robert C" uniqKey="Doebele R" first="Robert C" last="Doebele">Robert C. Doebele</name></author><author><name sortKey="Galasso, Cathy" sort="Galasso, Cathy" uniqKey="Galasso C" first="Cathy" last="Galasso">Cathy Galasso</name></author><author><name sortKey="Garon, Edward B" sort="Garon, Edward B" uniqKey="Garon E" first="Edward B" last="Garon">Edward B. Garon</name></author><author><name sortKey="Heist, Rebecca S" sort="Heist, Rebecca S" uniqKey="Heist R" first="Rebecca S" last="Heist">Rebecca S. Heist</name></author><author><name sortKey="Logan, Jennifer" sort="Logan, Jennifer" uniqKey="Logan J" first="Jennifer" last="Logan">Jennifer Logan</name></author><author><name sortKey="Neal, Joel W" sort="Neal, Joel W" uniqKey="Neal J" first="Joel W" last="Neal">Joel W. Neal</name></author><author><name sortKey="Mendenhall, Melody A" sort="Mendenhall, Melody A" uniqKey="Mendenhall M" first="Melody A" last="Mendenhall">Melody A. Mendenhall</name></author><author><name sortKey="Nichols, Suzanne" sort="Nichols, Suzanne" uniqKey="Nichols S" first="Suzanne" last="Nichols">Suzanne Nichols</name></author><author><name sortKey="Piotrowska, Zofia" sort="Piotrowska, Zofia" uniqKey="Piotrowska Z" first="Zofia" last="Piotrowska">Zofia Piotrowska</name></author><author><name sortKey="Wozniak, Antoinette J" sort="Wozniak, Antoinette J" uniqKey="Wozniak A" first="Antoinette J" last="Wozniak">Antoinette J. Wozniak</name></author><author><name sortKey="Raponi, Mitch" sort="Raponi, Mitch" uniqKey="Raponi M" first="Mitch" last="Raponi">Mitch Raponi</name></author><author><name sortKey="Karlovich, Chris A" sort="Karlovich, Chris A" uniqKey="Karlovich C" first="Chris A" last="Karlovich">Chris A. Karlovich</name></author><author><name sortKey="Jaw Tsai, Sarah" sort="Jaw Tsai, Sarah" uniqKey="Jaw Tsai S" first="Sarah" last="Jaw-Tsai">Sarah Jaw-Tsai</name></author><author><name sortKey="Isaacson, Jeffrey" sort="Isaacson, Jeffrey" uniqKey="Isaacson J" first="Jeffrey" last="Isaacson">Jeffrey Isaacson</name></author><author><name sortKey="Despain, Darrin" sort="Despain, Darrin" uniqKey="Despain D" first="Darrin" last="Despain">Darrin Despain</name></author><author><name sortKey="Matheny, Shannon L" sort="Matheny, Shannon L" uniqKey="Matheny S" first="Shannon L" last="Matheny">Shannon L. Matheny</name></author><author><name sortKey="Rolfe, Lindsey" sort="Rolfe, Lindsey" uniqKey="Rolfe L" first="Lindsey" last="Rolfe">Lindsey Rolfe</name></author><author><name sortKey="Allen, Andrew R" sort="Allen, Andrew R" uniqKey="Allen A" first="Andrew R" last="Allen">Andrew R. Allen</name></author><author><name sortKey="Camidge, D Ross" sort="Camidge, D Ross" uniqKey="Camidge D" first="D Ross" last="Camidge">D Ross Camidge</name></author></analytic><series><title level="j">The New England journal of medicine</title><idno type="eISSN">1533-4406</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acrylamides (administration & dosage)</term><term>Acrylamides (adverse effects)</term><term>Acrylamides (pharmacokinetics)</term><term>Aged</term><term>Antineoplastic Agents (administration & dosage)</term><term>Antineoplastic Agents (adverse effects)</term><term>Carcinoma, Non-Small-Cell Lung (drug therapy)</term><term>Carcinoma, Non-Small-Cell Lung (genetics)</term><term>Carcinoma, Non-Small-Cell Lung (pathology)</term><term>Dose-Response Relationship, Drug</term><term>Drug Resistance, Neoplasm (genetics)</term><term>Female</term><term>Humans</term><term>Hyperglycemia (chemically induced)</term><term>Lung Neoplasms (drug therapy)</term><term>Lung Neoplasms (genetics)</term><term>Lung Neoplasms (pathology)</term><term>Male</term><term>Middle Aged</term><term>Mutation</term><term>Protein Kinase Inhibitors (administration & dosage)</term><term>Protein Kinase Inhibitors (adverse effects)</term><term>Protein Kinase Inhibitors (pharmacokinetics)</term><term>Pyrimidines (administration & dosage)</term><term>Pyrimidines (adverse effects)</term><term>Pyrimidines (pharmacokinetics)</term><term>Receptor, Epidermal Growth Factor (antagonists & inhibitors)</term><term>Receptor, Epidermal Growth Factor (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acrylamides (administration et posologie)</term><term>Acrylamides (effets indésirables)</term><term>Acrylamides (pharmacocinétique)</term><term>Adulte d'âge moyen</term><term>Antinéoplasiques (administration et posologie)</term><term>Antinéoplasiques (effets indésirables)</term><term>Carcinome pulmonaire non à petites cellules (anatomopathologie)</term><term>Carcinome pulmonaire non à petites cellules (génétique)</term><term>Carcinome pulmonaire non à petites cellules (traitement médicamenteux)</term><term>Femelle</term><term>Humains</term><term>Hyperglycémie ()</term><term>Inhibiteurs de protéines kinases (administration et posologie)</term><term>Inhibiteurs de protéines kinases (effets indésirables)</term><term>Inhibiteurs de protéines kinases (pharmacocinétique)</term><term>Mutation</term><term>Mâle</term><term>Pyrimidines (administration et posologie)</term><term>Pyrimidines (effets indésirables)</term><term>Pyrimidines (pharmacocinétique)</term><term>Relation dose-effet des médicaments</term><term>Récepteur du facteur de croissance épidermique (antagonistes et inhibiteurs)</term><term>Récepteur du facteur de croissance épidermique (génétique)</term><term>Résistance aux médicaments antinéoplasiques (génétique)</term><term>Sujet âgé</term><term>Tumeurs du poumon (anatomopathologie)</term><term>Tumeurs du poumon (génétique)</term><term>Tumeurs du poumon (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Acrylamides</term><term>Antineoplastic Agents</term><term>Protein Kinase Inhibitors</term><term>Pyrimidines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Acrylamides</term><term>Antineoplastic Agents</term><term>Protein Kinase Inhibitors</term><term>Pyrimidines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Receptor, Epidermal Growth Factor</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptor, Epidermal Growth Factor</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Acrylamides</term><term>Protein Kinase Inhibitors</term><term>Pyrimidines</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Acrylamides</term><term>Antinéoplasiques</term><term>Inhibiteurs de protéines kinases</term><term>Pyrimidines</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinome pulmonaire non à petites cellules</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Récepteur du facteur de croissance épidermique</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Hyperglycemia</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Carcinoma, Non-Small-Cell Lung</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Acrylamides</term><term>Antinéoplasiques</term><term>Inhibiteurs de protéines kinases</term><term>Pyrimidines</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Carcinoma, Non-Small-Cell Lung</term><term>Drug Resistance, Neoplasm</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Carcinome pulmonaire non à petites cellules</term><term>Récepteur du facteur de croissance épidermique</term><term>Résistance aux médicaments antinéoplasiques</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma, Non-Small-Cell Lung</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pharmacocinétique" xml:lang="fr"><term>Acrylamides</term><term>Inhibiteurs de protéines kinases</term><term>Pyrimidines</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Carcinome pulmonaire non à petites cellules</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Dose-Response Relationship, Drug</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Mutation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Hyperglycémie</term><term>Mutation</term><term>Mâle</term><term>Relation dose-effet des médicaments</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Non-small-cell lung cancer (NSCLC) with a mutation in the gene encoding epidermal growth factor receptor (EGFR) is sensitive to approved EGFR inhibitors, but resistance develops, mediated by the T790M EGFR mutation in most cases. Rociletinib (CO-1686) is an EGFR inhibitor active in preclinical models of EGFR-mutated NSCLC with or without T790M.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Orsay</li></settlement><orgName><li>Université Paris-Sud</li></orgName></list><tree><noCountry><name sortKey="Aisner, Dara L" sort="Aisner, Dara L" uniqKey="Aisner D" first="Dara L" last="Aisner">Dara L. Aisner</name><name sortKey="Allen, Andrew R" sort="Allen, Andrew R" uniqKey="Allen A" first="Andrew R" last="Allen">Andrew R. Allen</name><name sortKey="Camidge, D Ross" sort="Camidge, D Ross" uniqKey="Camidge D" first="D Ross" last="Camidge">D Ross Camidge</name><name sortKey="Despain, Darrin" sort="Despain, Darrin" uniqKey="Despain D" first="Darrin" last="Despain">Darrin Despain</name><name sortKey="Doebele, Robert C" sort="Doebele, Robert C" uniqKey="Doebele R" first="Robert C" last="Doebele">Robert C. Doebele</name><name sortKey="Dziadziuszko, Rafal" sort="Dziadziuszko, Rafal" uniqKey="Dziadziuszko R" first="Rafal" last="Dziadziuszko">Rafal Dziadziuszko</name><name sortKey="Gadgeel, Shirish M" sort="Gadgeel, Shirish M" uniqKey="Gadgeel S" first="Shirish M" last="Gadgeel">Shirish M. Gadgeel</name><name sortKey="Galasso, Cathy" sort="Galasso, Cathy" uniqKey="Galasso C" first="Cathy" last="Galasso">Cathy Galasso</name><name sortKey="Garon, Edward B" sort="Garon, Edward B" uniqKey="Garon E" first="Edward B" last="Garon">Edward B. Garon</name><name sortKey="Goldman, Jonathan W" sort="Goldman, Jonathan W" uniqKey="Goldman J" first="Jonathan W" last="Goldman">Jonathan W. Goldman</name><name sortKey="Heist, Rebecca S" sort="Heist, Rebecca S" uniqKey="Heist R" first="Rebecca S" last="Heist">Rebecca S. Heist</name><name sortKey="Isaacson, Jeffrey" sort="Isaacson, Jeffrey" uniqKey="Isaacson J" first="Jeffrey" last="Isaacson">Jeffrey Isaacson</name><name sortKey="Jaw Tsai, Sarah" sort="Jaw Tsai, Sarah" uniqKey="Jaw Tsai S" first="Sarah" last="Jaw-Tsai">Sarah Jaw-Tsai</name><name sortKey="Karlovich, Chris A" sort="Karlovich, Chris A" uniqKey="Karlovich C" first="Chris A" last="Karlovich">Chris A. Karlovich</name><name sortKey="Logan, Jennifer" sort="Logan, Jennifer" uniqKey="Logan J" first="Jennifer" last="Logan">Jennifer Logan</name><name sortKey="Matheny, Shannon L" sort="Matheny, Shannon L" uniqKey="Matheny S" first="Shannon L" last="Matheny">Shannon L. Matheny</name><name sortKey="Mendenhall, Melody A" sort="Mendenhall, Melody A" uniqKey="Mendenhall M" first="Melody A" last="Mendenhall">Melody A. Mendenhall</name><name sortKey="Neal, Joel W" sort="Neal, Joel W" uniqKey="Neal J" first="Joel W" last="Neal">Joel W. Neal</name><name sortKey="Nichols, Suzanne" sort="Nichols, Suzanne" uniqKey="Nichols S" first="Suzanne" last="Nichols">Suzanne Nichols</name><name sortKey="Oxnard, Geoffrey R" sort="Oxnard, Geoffrey R" uniqKey="Oxnard G" first="Geoffrey R" last="Oxnard">Geoffrey R. Oxnard</name><name sortKey="Papadimitrakopoulou, Vassiliki" sort="Papadimitrakopoulou, Vassiliki" uniqKey="Papadimitrakopoulou V" first="Vassiliki" last="Papadimitrakopoulou">Vassiliki Papadimitrakopoulou</name><name sortKey="Piotrowska, Zofia" sort="Piotrowska, Zofia" uniqKey="Piotrowska Z" first="Zofia" last="Piotrowska">Zofia Piotrowska</name><name sortKey="Raponi, Mitch" sort="Raponi, Mitch" uniqKey="Raponi M" first="Mitch" last="Raponi">Mitch Raponi</name><name sortKey="Rolfe, Lindsey" sort="Rolfe, Lindsey" uniqKey="Rolfe L" first="Lindsey" last="Rolfe">Lindsey Rolfe</name><name sortKey="Solomon, Benjamin J" sort="Solomon, Benjamin J" uniqKey="Solomon B" first="Benjamin J" last="Solomon">Benjamin J. Solomon</name><name sortKey="Soria, Jean Charles" sort="Soria, Jean Charles" uniqKey="Soria J" first="Jean-Charles" last="Soria">Jean-Charles Soria</name><name sortKey="Varga, Andrea" sort="Varga, Andrea" uniqKey="Varga A" first="Andrea" last="Varga">Andrea Varga</name><name sortKey="Wakelee, Heather A" sort="Wakelee, Heather A" uniqKey="Wakelee H" first="Heather A" last="Wakelee">Heather A. Wakelee</name><name sortKey="Wozniak, Antoinette J" sort="Wozniak, Antoinette J" uniqKey="Wozniak A" first="Antoinette J" last="Wozniak">Antoinette J. Wozniak</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Sequist, Lecia V" sort="Sequist, Lecia V" uniqKey="Sequist L" first="Lecia V" last="Sequist">Lecia V. Sequist</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002862 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002862 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:25923550
|texte= Rociletinib in EGFR-mutated non-small-cell lung cancer.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25923550" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |